I actually don't use any keyword tools aside from Google Trends, but only rarely do I even use that. I try to talk to many of our target audience members (entrepreneurs) as I can. I attend events, I have phone calls, I sit next to them while working. Generally speaking, I think it's a waste of time to START with keyword tools instead of actual customers. Yes, you can target people in broad swaths and get a high level sense for what's interesting and trending, but at least in the case of our business at NextView Ventures, it's way more powerful to talk to actual "customers" you serve.
Long Tail Pro is a keyword research tool that helps you quickly find low competition keywords for your website. In particular, the tool is built for people doing SEO (search engine optimization) as opposed to people doing paid ads (Google Adwords PPC). I'm sure there are some advertisers that use the tool for paid ad keyword research, but the tool was built for SEO keyword research.